20 Week, 2025: Semaglutide reverses liver fibrosis and klotho gene extends mouse lifespan

A groundbreaking trial shows semaglutide not only resolves steatohepatitis in nearly 63% of patients but also significantly reduces liver fibrosis, marking a pivotal shift toward actual tissue repair in fatty liver disease and opening doors to fewer complications and longer healthspan.

Semaglutide Therapy Reverses Liver Fibrosis in MASH Patients

An international, double-blind, placebo-controlled trial at 253 sites demonstrates that weekly subcutaneous semaglutide (2.4 mg) resolves steatohepatitis in 62.9% of patients and reduces fibrosis in 36.8%. The study assesses histological endpoints via liver biopsies at baseline and week 72, offering a promising pharmacological strategy against metabolic dysfunction-associated steatohepatitis.

Key points:

• Weekly 2.4 mg subcutaneous semaglutide resolves steatohepatitis without fibrosis worsening in 62.9% of MASH patients.
• Semaglutide achieves 36.8% fibrosis reduction without steatohepatitis exacerbation versus 22.4% with placebo.
• Paired liver biopsies at baseline and week 72 assess co-primary histological endpoints.
• Trial spans 253 sites in 37 countries with 800 participants, 56% of whom have type 2 diabetes.
• Semaglutide group shows mean weight loss of 10.5% and improved metabolic markers (HOMA-IR, hsCRP).
• Adverse events are predominantly gastrointestinal, with serious event rates similar to placebo.

Why it matters: These findings shift the treatment paradigm for advanced fatty liver disease by demonstrating histological reversal rather than merely symptom relief. Semaglutide’s dual modulation of hepatic inflammation and systemic metabolism offers a multifunctional therapeutic approach that could prevent progression to cirrhosis and decrease cardiometabolic complications.

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Single Klotho Dose Extends Mouse Lifespan and Protects Multiple Tissues

A team at the University of Barcelona employs adeno-associated virus serotype 9 to deliver the Klotho gene in adult mice. The single-dose treatment elevates s-KL protein levels systemically and in the brain, yielding nearly 20% longer lifespans alongside preserved muscle function, bone volume and cognitive resilience. Their findings illustrate a multi-organ anti-aging approach targeting fundamental longevity processes rather than individual diseases.

Key points:

• AAV9-mediated delivery of s-KL via intravenous and intracerebroventricular injections in mice
• 19.7% lifespan extension with preserved muscle, bone and cognitive functions
• Enhanced muscle regeneration, improved trabecular bone architecture and increased hippocampal neurogenesis

Why it matters: Targeting Klotho offers a unified, multi-tissue anti-aging approach that could transform longevity medicine beyond single-disease treatments.

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Wonderfeel Unveils 900mg NMN Formula for Superior Cellular Health

The dietary supplement company Wonderfeel introduces its 900 mg NMN formulation, Youngr™, designed to elevate intracellular NAD+ levels and support cellular repair pathways. The clinical-strength blend combines NMN with complementary actives—trans-resveratrol, vitamin D3, olive fruit extract, and ergothioneine—to optimize antioxidant protection and metabolic energy.

Key points:

• Provides 900 mg NMN per serving to boost NAD+ and enhance cellular bioenergetics.
• Synergistic formula includes trans-resveratrol, vitamin D3, olive fruit extract, and ergothioneine for antioxidant support.
• Manufactured in a cGMP-certified US facility with third-party purity and potency testing.

Why it matters: This high-potency formulation offers a scalable strategy to counteract age-related NAD+ decline, potentially transforming preventive longevity interventions.

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Whoop 5.0 advances healthspan tracking but falters on HR accuracy

Whoop, the wearables manufacturer, releases the 5.0 tracker with extended battery life, tiered subscriptions, Healthspan biomarker scores, and on-demand ECG via its MG model, refining its platform to focus on longevity and holistic health insights.

Key points:

• Tiered subscriptions offer three levels—including Whoop One, Peak, and Life—unlocking features from basic sleep and strain metrics to medical-grade ECG and beta blood pressure insights.
• Healthspan metric aggregates nine biomarkers—heart rate zones, sleep consistency, VO2 max, and lean body mass—to calculate physiological age and Pace of Aging.
• Hardware upgrades deliver a 14-day battery life, new wireless PowerPack, and redesigned module with optical sensors for ECG and non-invasive blood pressure estimation.

Why it matters: This update positions Whoop at the forefront of longevity-focused wearables by combining extended battery life with actionable biomarker analytics previously limited to clinical settings.

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Tom Cruise’s Trainer Unveils Nine Science-Backed Longevity Secrets

Led by Tom Cruise’s longtime trainer, a nine-step regimen emphasizes dynamic stretching, strategic HIIT, precise hydration, anti-inflammatory nutrition, quality sleep, strength training, mindfulness, and cold exposure. Each practice targets cellular aging pathways—boosting synovial fluid, growth hormone, mitochondrial function, autophagy, and stress resilience—to support sustained vitality and slow biological aging across all fitness levels.

Key points:

• Dynamic stretching increases synovial fluid production and restores joint range of motion.
• 20-minute HIIT sessions elevate growth hormone by over 500%, enhancing muscle preservation and metabolic health.
• Cold exposure induces heat-shock proteins and activates brown adipose tissue, improving cellular repair and energy metabolism.

Why it matters: By integrating simple, science-backed daily practices, this regimen offers a scalable strategy to delay aging and enhance long-term healthspan.

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Ten Foods That Unlock the Secret to Healthy Aging

Katie Fry and the Revive Rejoice health editors present ten scientifically supported anti-aging foods, from extra virgin olive oil to pomegranates, explaining how their key nutrients and antioxidants combat oxidative stress and support collagen, brain, and cardiovascular health.

Key points:

• Extra virgin olive oil supplies 73% MUFAs and phenolic antioxidants to reduce inflammation and oxidative stress.
• Green tea EGCG and polyphenols neutralize free radicals, protect brain cells, and support UV defense.
• Omega-3 fatty acids from fatty fish and flaxseed maintain cell membranes, reduce inflammation, and stimulate collagen synthesis.

Why it matters: Highlighting evidence-based dietary choices empowers individuals to leverage natural compounds for slowing cellular aging and reducing chronic disease risk.

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Biohacking fuels women’s personalized longevity routines

Wellness entrepreneur Kayla Barnes collaborates with clinicians to implement a comprehensive biohacking regimen, employing technologies such as PEMF mats, Oura ring biometrics, red/blue light therapy, and hyperbaric oxygen. By customizing nutrition, exercise, and recovery protocols to menstrual cycles, this approach seeks to fortify bone density, optimize metabolic health, and slow age-related decline in women seeking personalized longevity solutions.

Key points:

• Daily biohacking integrates PEMF therapy, red/blue light, and hyperbaric oxygen for systemic health benefits.
• Biometric tracking with Oura ring and bioelectrical impedance guides personalized nutrition, sleep, and exercise adjustments.
• Hormonal-cycle alignment informs sauna, cold therapy, and oxygen protocols to optimize bone density and metabolic function.
• Advanced modalities—NanoVi oxygen delivery, intranasal photobiomodulation, LYMA Laser—target cellular repair and cognitive support.
• Continuous monitoring of telomere length and metabolic markers underpins protocol efficacy and long-term healthspan goals.

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